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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M TICLOPIDINE (is an active metabolite)
| TICLOPIDINE | BLOOD | - | P2Y PURINOCEPTOR 12 | P2Y purinoceptor 12 UNIPROT Q9H244 P2RY12 more at DrugCentral | EMA | ||||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TICLOPIDINE (has an active metabolite)
| TICLOPIDINE | BLOOD | ORAL | Tmax 2 HOUR F 80 PERCENT PPB 98 PERCENT HT 108 HOUR SOLUBILITY FREELY SOLUBLE IN WATER | P2Y PURINOCEPTOR 12 PDB 3KW4 (CRYSTAL STRUCTURE OF CYTOCHROME 2B4 IN COMPLEX WITH THE ANTI-PLATELET DRUG TICLOPIDINE) LIGAND CODE = TIC (link to the list of PDB complexes) Download experimental 3D coordinates of TIC with added hydrogens | P2Y purinoceptor 12 UNIPROT Q9H244 P2RY12 more at DrugCentral | EMA | |||
