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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M ZALCITABINE (is an active metabolite)
| ZALCITABINE | ANTIINFECTIVES | - | HIV REVERSE TRANSCRIPTASE (GAG-POL) DNA POLYMERASE-BETA MITOCHONDRIAL DNA POLYMERASE-GAMMA PDB 4DQP (TERNARY COMPLEX OF BACILLUS DNA POLYMERASE I LARGE FRAGMENT, DNA DUPLEX, AND DDCTP (PAIRED WITH DG OF TEMPLATE)) LIGAND CODE = DCT (link to the list of PDB complexes) Download experimental 3D coordinates of DCT with added hydrogens | Reverse transcriptase,RNaseH UNIPROT Q72547 pol more at DrugCentral | EMA | ||||
