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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M AMIFOSTINE (is an active metabolite)
| AMIFOSTINE | VARIOUS | - | Cmax 35 MICROMOLAR HT 0.13 HOUR | ALKALINE PHOSPHATASE PDB 7NIZ (HUMAN 14-3-3 SIGMA IN COMPLEX WITH HUMAN ESTROGEN RECEPTOR ALPHA PEPTIDE AND LIGANDS FUSICOCCIN-A AND WR-1065) LIGAND CODE = UGH (link to the list of PDB complexes) Download experimental 3D coordinates of UGH with added hydrogens | Unknown more at DrugCentral | EMA | |||
