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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M GEMCITABINE (is an active metabolite)
| GEMCITABINE | ANTINEOPLASTIC | - | DEOXYCYTIDINE KINASE PDB 3MDC (DNA POLYMERASE LAMBDA IN COMPLEX WITH DFDCTP) LIGAND CODE = GTF (link to the list of PDB complexes) Download experimental 3D coordinates of GTF with added hydrogens | Ribonucleoside-diphosphate reductase large subunit UNIPROT P23921 RRM1 -- Ribonucleoside-diphosphate reductase subunit M2 UNIPROT P31350 RRM2 more at DrugCentral | EMA | ||||
