Cheminformatic Tools and Databases for Pharmacology

session 76803 - Total of 2 hits - Display   hits per page:

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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
CIDOFOVIR (is an active metabolite) (has an active metabolite)

CIDOFOVIR


ATC J05AB12

ANTIINFECTIVES
ANTIVIRAL
SUPPRESS CYTOMEGALOVIRUS (CMV) REPLICATION
CMV DNA POLYMERASE INHIBITOR

INJECTION

Cmax 70.2 MICROMOLAR

VD 26.6 LITER (65 KILOGRAM)

PPB 6 PERCENT

Cl 8.8 LITER / HOUR

HT 2.6 HOUR

SOLUBILITY 170 MILLIGRAM / MILLILITER IN WATER

DNA POLYMERASE

PDB 5KM8 (HUMAN HISTIDINE TRIAD NUCLEOTIDE BINDING PROTEIN 2 (HHINT2) CIDOFOVIR COMPLEX)

LIGAND CODE = L8P (link to the list of PDB complexes)

Download experimental 3D coordinates of L8P with added hydrogens

HUMAN HERPESVIRUS 1 DNA POLYMERASE INHIBITOR CHEMBL1872 HUMAN HERPESVIRUS 1 DNA POLYMERASE P04293 DNA POLYMERASE CATALYTIC SUBUNIT HERPES SIMPLEX VIRUS (TYPE 1 / STRAIN 17) ENZYME TRANSFERASEANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

2 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
M CIDOFOVIR (is an active metabolite)

CIDOFOVIR


ATC J05AB12

ANTIINFECTIVES
ANTIVIRAL
SUPPRESS CYTOMEGALOVIRUS (CMV) REPLICATION
CMV DNA POLYMERASE INHIBITOR

- DNA POLYMERASE

HUMAN HERPESVIRUS 1 DNA POLYMERASE INHIBITOR CHEMBL1872 HUMAN HERPESVIRUS 1 DNA POLYMERASE P04293 DNA POLYMERASE CATALYTIC SUBUNIT HERPES SIMPLEX VIRUS (TYPE 1 / STRAIN 17) ENZYME TRANSFERASEANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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