Cheminformatic Tools and Databases for Pharmacology

session 59461 - Total of 3 hits - Display   hits per page:

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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
M SIBUTRAMINE (is an active metabolite)

SIBUTRAMINE


ATC A08AA10

METABOLISM
ANOREXIC
ANTIDEPRESSANT
ANTI-OBESITY
NOREPINEPHRINE, SEROTONIN AND DOPAMINE REUPTAKE INHIBITOR

-

Cmax 25.4 NANOMOLAR

Tmax 3.5 HOUR

PPB 94 PERCENT

HT 16 HOUR

MONOAMINE REUPTAKE

MONOAMINE TRANSPORTER INHIBITOR CHEMBL2363064 MONOAMINE TRANSPORTER P23975 SODIUM-DEPENDENT NORADRENALINE TRANSPORTER HOMO SAPIENS TRANSPORTER ELECTROCHEMICAL SLC SLC06ANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

2 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
SIBUTRAMINE DISCONTINUED (has an active metabolite)

SIBUTRAMINE


ATC A08AA10

METABOLISM
ANOREXIC
ANTIDEPRESSANT
ANTI-OBESITY
NOREPINEPHRINE, SEROTONIN AND DOPAMINE REUPTAKE INHIBITOR

ORAL

Tmax 1.2 HOUR

PPB 97 PERCENT

Cl 1750 LITER / HOUR

HT 1.1 HOUR

SOLUBILITY 2.9 MILLIGRAM / MILLILITER IN PH 5.2

MONOAMINE REUPTAKE

MONOAMINE TRANSPORTER INHIBITOR CHEMBL2363064 MONOAMINE TRANSPORTER P23975 SODIUM-DEPENDENT NORADRENALINE TRANSPORTER HOMO SAPIENS TRANSPORTER ELECTROCHEMICAL SLC SLC06ANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

3 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
SIBUTRAMINE DISCONTINUED (has an active metabolite)

SIBUTRAMINE


ATC A08AA10

METABOLISM
ANOREXIC
ANTIDEPRESSANT
ANTI-OBESITY
NOREPINEPHRINE, SEROTONIN AND DOPAMINE REUPTAKE INHIBITOR

ORAL

Tmax 1.2 HOUR

PPB 97 PERCENT

Cl 1750 LITER / HOUR

HT 1.1 HOUR

SOLUBILITY 2.9 MILLIGRAM / MILLILITER IN PH 5.2

MONOAMINE REUPTAKE

MONOAMINE TRANSPORTER INHIBITOR CHEMBL2363064 MONOAMINE TRANSPORTER P23975 SODIUM-DEPENDENT NORADRENALINE TRANSPORTER HOMO SAPIENS TRANSPORTER ELECTROCHEMICAL SLC SLC06ANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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