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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
M SIBUTRAMINE (is an active metabolite)

SIBUTRAMINE


ATC A08AA10

METABOLISM
ANOREXIC
ANTIDEPRESSANT
ANTI-OBESITY
NOREPINEPHRINE, SEROTONIN AND DOPAMINE REUPTAKE INHIBITOR

-

Cmax 25.4 NANOMOLAR

Tmax 3.5 HOUR

PPB 94 PERCENT

HT 16 HOUR

MONOAMINE REUPTAKE

Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2

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