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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
CYCLOGUANIL (is an active metabolite)

CYCLOGUANIL


ATC P01BB01
ATC P01BB51
ATC P01BB02

ANTIPARASITIC
ANTIMALARIAL
ANTIMETABOLITES
DIHYDROFOLATE REDUCTASE INHIBITOR

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Tmax 5 HOUR

HT 19 HOUR

DIHYDROFOLATE REDUCTASE

PDB 3UM8 (WILD-TYPE PLASMODIUM FALCIPARUM DHFR-TS COMPLEXED WITH CYCLOGUANIL AND NADPH)

LIGAND CODE = 1CY (link to the list of PDB complexes)

Download experimental 3D coordinates of 1CY with added hydrogens

DIHYDROFOLATE REDUCTASE INHIBITOR CHEMBL1939 DIHYDROFOLATE REDUCTASE P13922 BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE PLASMODIUM FALCIPARUM K1 ENZYME REDUCTASEANSM (in French)

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