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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
GANCICLOVIR (is an active metabolite) (has an active metabolite)

GANCICLOVIR


ATC J05AB06
ATC S01AD09

ANTIINFECTIVES
ANTIVIRAL
CYTOMEGALOVIRUS (CMV)
HERPES SIMPLEX VIRUS (HSV)
ACYCLIC NUCLEOSIDE ANALOGUE OF 2'-DEOXYGUANOSINE

INJECTION ORAL IMPLANTATION OPHTHALMIC INTRAVENOUS

Cmax 26.7 MICROMOLAR

Tmax 2 HOUR

VD 45.7 LITER (65 KILOGRAM)

PPB 1 PERCENT

Cl 11.9 LITER / HOUR

HT 3.81 HOUR

SOLUBILITY APPROXIMATELY 6 MILLIGRAM / MILLILITER AT 37 DEGREE CELSIUS

THYMIDINE KINASE

PDB 1KI2 (THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I)

LIGAND CODE = GA2 (link to the list of PDB complexes)

Download experimental 3D coordinates of GA2 with added hydrogens

HUMAN HERPESVIRUS 1 DNA POLYMERASE INHIBITOR CHEMBL1872 HUMAN HERPESVIRUS 1 DNA POLYMERASE P04293 DNA POLYMERASE CATALYTIC SUBUNIT HERPES SIMPLEX VIRUS (TYPE 1 / STRAIN 17) ENZYME TRANSFERASEANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

2 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
M GANCICLOVIR (is an active metabolite)

GANCICLOVIR


ATC J05AB06
ATC S01AD09

ANTIINFECTIVES
ANTIVIRAL
CYTOMEGALOVIRUS (CMV)
HERPES SIMPLEX VIRUS (HSV)
COMPETITIVE INHIBITION OF VIRAL DNA POLYMERASES
INCORPORATION INTO VIRAL DNA RESULTING IN EVENTUAL TERMINATION OF VIRAL DNA ELONGATION
NUCLEOSIDE ANALOGUE

-

HUMAN HERPESVIRUS 1 DNA POLYMERASE INHIBITOR CHEMBL1872 HUMAN HERPESVIRUS 1 DNA POLYMERASE P04293 DNA POLYMERASE CATALYTIC SUBUNIT HERPES SIMPLEX VIRUS (TYPE 1 / STRAIN 17) ENZYME TRANSFERASEANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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