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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| GANCICLOVIR (is an active metabolite) (has an active metabolite)
| GANCICLOVIR | ANTIINFECTIVES | INJECTION ORAL IMPLANTATION OPHTHALMIC INTRAVENOUS | Cmax 26.7 MICROMOLAR Tmax 2 HOUR VD 45.7 LITER (65 KILOGRAM) PPB 1 PERCENT Cl 11.9 LITER / HOUR HT 3.81 HOUR SOLUBILITY APPROXIMATELY 6 MILLIGRAM / MILLILITER AT 37 DEGREE CELSIUS | THYMIDINE KINASE PDB 1KI2 (THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I) LIGAND CODE = GA2 (link to the list of PDB complexes) Download experimental 3D coordinates of GA2 with added hydrogens | HUMAN HERPESVIRUS 1 DNA POLYMERASE INHIBITOR CHEMBL1872 HUMAN HERPESVIRUS 1 DNA POLYMERASE P04293 DNA POLYMERASE CATALYTIC SUBUNIT HERPES SIMPLEX VIRUS (TYPE 1 / STRAIN 17) ENZYME TRANSFERASE | ANSM (in French) | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M GANCICLOVIR (is an active metabolite)
| GANCICLOVIR | ANTIINFECTIVES | - | HUMAN HERPESVIRUS 1 DNA POLYMERASE INHIBITOR CHEMBL1872 HUMAN HERPESVIRUS 1 DNA POLYMERASE P04293 DNA POLYMERASE CATALYTIC SUBUNIT HERPES SIMPLEX VIRUS (TYPE 1 / STRAIN 17) ENZYME TRANSFERASE | ANSM (in French) | |||||
