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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
M NELARABINE (is an active metabolite)

NELARABINE


ATC L01BB07

ANTINEOPLASTIC
TREATMENT OF PATIENTS WITH T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA AND T-CELL LYMPHOBLASTIC LYMPHOMA
FOR INCORPORATION INTO DE OXYRIBONUCLEIC ACID (DNA)

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Cmax 86.5 MICROMOLAR

VD 80 LITER

PPB 25 PERCENT

Cl 16.9 LITER / HOUR

HT 3.2 HOUR

DNA

DNA POLYMERASE ALPHA CATALYTIC SUBUNIT P09884 DNA POLYMERASE ALPHA CATALYTIC SUBUNIT HOMO SAPIENS ENZYME TRANSFERASEANSM (in French)

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SIDER side effects

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ChEMBL
BindingDB
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