Cheminformatic Tools and Databases for Pharmacology

session 99319 - Total of 2 hits - Display   hits per page:

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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
M TETRABENAZINE (is an active metabolite)

TETRABENAZINE


ATC N07XX06

NERVOUS SYSTEM
CNS
TREATMENT OF CHOREA ASSOCIATED WITH HUNTINGTON DISEASE
INHIBITOR
IS BELIEVED TO BE RELATED TO ITS EFFECT AS A REVERSIBLE DEPLETOR OF MONOAMINES (SUCH AS DOPAMINE, SEROTONIN, NOREPINEPHRINE, AND HISTAMINE) FROM NERVE TERMINALS
VESICULAR MONOAMINE TRANSPORTER TYPE 2 (VMAT2) (KI=100 NANOMOLAR)

-

Tmax 1 HOUR

PPB 61 PERCENT

HT 5 HOUR

VESICULAR MONOAMINE TRANSPORTER TYPE 2 (VMAT2)

SYNAPTIC VESICULAR AMINE TRANSPORTER INHIBITOR CHEMBL1893 SYNAPTIC VESICULAR AMINE TRANSPORTER Q05940 SYNAPTIC VESICULAR AMINE TRANSPORTER HOMO SAPIENS TRANSPORTER ELECTROCHEMICAL SLC SLC18ANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

2 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
TETRABENAZINE (has an active metabolite)

TETRABENAZINE


ATC N07XX06

NERVOUS SYSTEM
CNS
TREATMENT OF CHOREA ASSOCIATED WITH HUNTINGTON DISEASE
INHIBITOR
IS BELIEVED TO BE RELATED TO ITS EFFECT AS A REVERSIBLE DEPLETOR OF MONOAMINES (SUCH AS DOPAMINE, SEROTONIN, NOREPINEPHRINE, AND HISTAMINE) FROM NERVE TERMINALS
VESICULAR MONOAMINE TRANSPORTER TYPE 2 (VMAT2) (KI=100 NANOMOLAR)

ORAL

F 75 PERCENT

PPB 84 PERCENT

SOLUBILITY SPARINGLY SOLUBLE IN WATER

VESICULAR MONOAMINE TRANSPORTER TYPE 2 (VMAT2)

SYNAPTIC VESICULAR AMINE TRANSPORTER INHIBITOR CHEMBL1893 SYNAPTIC VESICULAR AMINE TRANSPORTER Q05940 SYNAPTIC VESICULAR AMINE TRANSPORTER HOMO SAPIENS TRANSPORTER ELECTROCHEMICAL SLC SLC18ANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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