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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
M TETRABENAZINE (is an active metabolite)

TETRABENAZINE


ATC N07XX06

NERVOUS SYSTEM
CNS
TREATMENT OF CHOREA ASSOCIATED WITH HUNTINGTON DISEASE
INHIBITOR
IS BELIEVED TO BE RELATED TO ITS EFFECT AS A REVERSIBLE DEPLETOR OF MONOAMINES (SUCH AS DOPAMINE, SEROTONIN, NOREPINEPHRINE, AND HISTAMINE) FROM NERVE TERMINALS
VESICULAR MONOAMINE TRANSPORTER TYPE 2 (VMAT2) (KI=100 NANOMOLAR)

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Tmax 1 HOUR

PPB 61 PERCENT

HT 5 HOUR

VESICULAR MONOAMINE TRANSPORTER TYPE 2 (VMAT2)

SYNAPTIC VESICULAR AMINE TRANSPORTER INHIBITOR CHEMBL1893 SYNAPTIC VESICULAR AMINE TRANSPORTER Q05940 SYNAPTIC VESICULAR AMINE TRANSPORTER HOMO SAPIENS TRANSPORTER ELECTROCHEMICAL SLC SLC18ANSM (in French)

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