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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
BAZEDOXIFENE

BAZEDOXIFENE


ATC G03XC02
ATC G03CC07

GENITO
TREATMENT OF MODERATE TO SEVERE VASOMOTOR SYMPTOMS ASSOCIATED WITH MENOPAUSE
AGONIST OF ESTROGEN RECEPTORS (ER) ALPHA AND BETA

ORAL

Cmax 14.6 NANOMOLAR

F 6 PERCENT

VD 882 LITER (60 KILOGRAM)

PPB 98 PERCENT

Cl 24 LITER / HOUR (60 KILOGRAM)

HT 30 HOUR

SOLUBILITY PH DEPENDENT IN WATER (923 MICROGRAM / MILLILITER AT PH 5.4)

ESTROGEN RECEPTOR ALPHA
ESTROGEN RECEPTOR BETA

PDB 4XI3 (ESTROGEN RECEPTOR ALPHA LIGAND BINDING DOMAIN IN COMPLEX WITH BAZEDOXIFENE)

LIGAND CODE = 29S (link to the list of PDB complexes)

Download experimental 3D coordinates of 29S with added hydrogens

ESTROGEN RECEPTOR MODULATOR CHEMBL2093866 ESTROGEN RECEPTOR P03372 ESTROGEN RECEPTOR HOMO SAPIENS TRANSCRIPTION FACTOR NUCLEAR RECEPTOR NR3 NR3A NR3A1ANSM (in French)

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