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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
SIMEPREVIR DISCONTINUED

SIMEPREVIR


ATC J05AE14
ATC J05AP05

ANTIINFECTIVES
HEPATITIS C VIRUS (HCV) NS3/4A PROTEASE INHIBITOR
TREATMENT OF CHRONIC HEPATITIS C (CHC) INFECTION
A SUBSTRATE OF P-GP

ORAL

Cmax 2.58 MICROMOLAR

Tmax 5 HOUR

F 62 PERCENT

PPB 99.9 PERCENT

HT 25.5 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER

HEPATITIS C VIRUS (HCV) NS3/4A PROTEASE

PDB 3KEE (HCV NS3/NS4A COMPLEXED WITH NON-COVALENT MACROCYCLIC COMPOUND TMC435)

LIGAND CODE = 30B (link to the list of PDB complexes)

Download experimental 3D coordinates of 30B with added hydrogens

HEPATITIS C VIRUS SERINE PROTEASE, NS3/NS4A INHIBITOR CHEMBL2095231 HEPATITIS C VIRUS SERINE PROTEASE, NS3/NS4A A3EZI9 NS3 HEPATITIS C VIRUS ENZYME PROTEASE SERINE PAS S29ANSM (in French)

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