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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| AFATINIB
| AFATINIB | ANTINEOPLASTIC | ORAL | Tmax 3.5 HOUR F 92 PERCENT PPB 95 PERCENT HT 37 HOUR SOLUBILITY SOLUBLE IN WATER | EGFR (ERBB1) HER2 (ERBB2) HER4 (ERBB4) PDB 4G5J (CRYSTAL STRUCTURE OF EGFR KINASE IN COMPLEX WITH BIBW2992) LIGAND CODE = 0WM (link to the list of PDB complexes) Download experimental 3D coordinates of 0WM with added hydrogens | Epidermal growth factor receptor UNIPROT P00533 EGFR -- Receptor tyrosine-protein kinase erbB-2 UNIPROT P04626 ERBB2 more at DrugCentral | EMA | |||
