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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
RIOCIGUAT

RIOCIGUAT


ATC C02KX05

CARDIOVASCULAR
ANTIHYPERTENSIVE
PERSISTENT/RECURRENT CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION (CTEPH)
PULMONARY ARTERIAL HYPERTENSION (PAH)
GUANYLATE CYCLASE (SGC) STIMULATOR (RECEPTOR FOR NITRIC OXIDE (NO))

ORAL

F 94 PERCENT

VD 30 LITER

PPB 95 PERCENT

Cl 2.6 LITER / HOUR

HT 9.5 HOUR

SOLUBILITY IN WATER (4 MILLIGRAM / LITER)

SOLUBLE GUANYLATE CYCLASE

SOLUBLE GUANYLATE CYCLASE POSITIVE ALLOSTERIC MODULATOR CHEMBL2111348 SOLUBLE GUANYLATE CYCLASE O75343 GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2 HOMO SAPIENS ENZYME LYASE GUANYLATE CYCLASE SOLUBLE GUANYLATE CYCLASEANSM (in French)

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