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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
NORFLUOXETINE (is an active metabolite)

NORFLUOXETINE


ATC N06AB03
ATC N06CA03

NERVOUS SYSTEM
ANTIDEPRESSANT
SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRIS)
INHIBITION OF CNS NEURONAL UPTAKE OF SEROTONIN

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Cmax 559 NANOMOLAR

HT 240 HOUR

SODIUM-DEPENDENT SEROTONIN TRANSPORTER

PDB 4XDK (CRYSTAL STRUCTURE OF HUMAN TWO PORE DOMAIN POTASSIUM ION CHANNEL TREK2 (K2P10.1) IN COMPLEX WITH NORFLUOXETINE)

LIGAND CODE = 405 (link to the list of PDB complexes)

Download experimental 3D coordinates of 405 with added hydrogens

SEROTONIN TRANSPORTER INHIBITOR CHEMBL228 SEROTONIN TRANSPORTER P31645 SODIUM-DEPENDENT SEROTONIN TRANSPORTER HOMO SAPIENS TRANSPORTER ELECTROCHEMICAL SLC SLC06ANSM (in French)

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