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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PHENYLACETATE (is an active metabolite)
| PHENYLACETATE | NATURAL MOLECULE (link) NITROGEN-BINDING AGENT FOR CHRONIC UREAC CYCLE DISORDERS (UCDS) | - | Cmax 205.8 MICROMOLAR Tmax 3.7 HOUR PPB 51 PERCENT HT 1.15 HOUR SOLUBILITY SOLUBLE IN WATER | PHENYLACETYL-COA: L-GLUTAMINE-N-ACETYLTRANSFERASE PDB 2ISF (CRYSTAL STRUCTURE OF C298A W219Y ALDOSE REDUCTASE COMPLEXED WITH PHENYLACETIC ACID) LIGAND CODE = PAC (link to the list of PDB complexes) Download experimental 3D coordinates of PAC with added hydrogens | Unknown more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PHENYLBUTYRATE (is an active metabolite) (has an active metabolite)
| PHENYLBUTYRATE | METABOLISM | ORAL | Cmax 1.32 MILLIMOLAR (5 GRAMS) Tmax 1 HOUR PPB 89 PERCENT HT 0.77 HOUR SOLUBILITY SOLUBLE IN WATER | PHENYLACETYL-COA: L-GLUTAMINE-N-ACETYLTRANSFERASE PDB 3TZ2 (CRYSTAL STRUCTURE OF BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE KINASE, PHENYLBUTYRATE COMPLEX) LIGAND CODE = CLT (link to the list of PDB complexes) Download experimental 3D coordinates of CLT with added hydrogens | Unknown more at DrugCentral | EMA | |||
