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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| GLYCEROL PHENYLBUTYRATE (has an active metabolite)
| GLYCEROL PHENYLBUTYRATE | NITROGEN-BINDING AGENT FOR CHRONIC UREAC CYCLE DISORDERS (UCDS) | ORAL | SOLUBILITY INSOLUBLE IN WATER | PANCREATIC TRIGLYCERIDE LIPASE CARBOXYL ESTER LIPASE PANCREATIC LIPASE RELATED PROTEIN 2 HUMAN ESTERASES | Unknown more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PHENYLBUTYRATE (is an active metabolite) (has an active metabolite)
| PHENYLBUTYRATE | METABOLISM | ORAL | Cmax 1.32 MILLIMOLAR (5 GRAMS) Tmax 1 HOUR PPB 89 PERCENT HT 0.77 HOUR SOLUBILITY SOLUBLE IN WATER | PHENYLACETYL-COA: L-GLUTAMINE-N-ACETYLTRANSFERASE PDB 3TZ2 (CRYSTAL STRUCTURE OF BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE KINASE, PHENYLBUTYRATE COMPLEX) LIGAND CODE = CLT (link to the list of PDB complexes) Download experimental 3D coordinates of CLT with added hydrogens | Unknown more at DrugCentral | EMA | |||
