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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TRAMETINIB
| TRAMETINIB | ANTINEOPLASTIC | ORAL | F 72 PERCENT VD 214 LITER PPB 97.4 PERCENT Cl 4.9 LITER / HOUR HT 4.35 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN THE PH RANGE OF 2 TO 8 IN WATER | MEK1 MEK2 PDB 7JUR (CRYSTAL STRUCTURE OF KSR2:MEK1 IN COMPLEX WITH AMP-PNP AND ALLOSTERIC MEK INHIBITOR TRAMETINIB) LIGAND CODE = QOM (link to the list of PDB complexes) Download experimental 3D coordinates of QOM with added hydrogens | Dual specificity mitogen-activated protein kinase kinase 1 UNIPROT Q02750 MAP2K1 -- Dual specificity mitogen-activated protein kinase kinase 2 UNIPROT P36507 MAP2K2 more at DrugCentral | EMA | |||
