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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PONATINIB
| PONATINIB | ANTINEOPLASTIC | ORAL | Cmax 0.13 MICROMOLAR VD 1223 LITER PPB 99 PERCENT Cl 35.3 LITER / HOUR (EQN) HT 24 HOUR SOLUBILITY 0.16 MCG / MILLILITER AT PH 7 | ABL PDB 3ZOS (STRUCTURE OF THE DDR1 KINASE DOMAIN IN COMPLEX WITH PONATINIB) LIGAND CODE = 0LI (link to the list of PDB complexes) Download experimental 3D coordinates of 0LI with added hydrogens | Tyrosine-protein kinase ABL1 UNIPROT P00519 ABL1 -- Breakpoint cluster region protein UNIPROT P11274 BCR more at DrugCentral | EMA | |||
