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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
PONATINIB

PONATINIB


ATC L01XE24

ANTINEOPLASTIC
TYROSINE KINASE INHIBITOR ABL (IC50 = 0.4 NANOMOLAR)
TREATMENT OF CHRONIC MYELOID LEUKEMIA (CML)
VEGFR, PDGFR, FGFR, EPH RECEPTORS AND SRC FAMILIES OF KINASES AND KIT, RET, TIE2, AND FLT3 WITH IC50 CONCENTRATIONS BETWEEN 0.1 AND 20 NANOMOLAR

ORAL

Cmax 0.13 MICROMOLAR

VD 1223 LITER

PPB 99 PERCENT

Cl 35.3 LITER / HOUR (EQN)

HT 24 HOUR

SOLUBILITY 0.16 MCG / MILLILITER AT PH 7

ABL

PDB 3ZOS (STRUCTURE OF THE DDR1 KINASE DOMAIN IN COMPLEX WITH PONATINIB)

LIGAND CODE = 0LI (link to the list of PDB complexes)

Download experimental 3D coordinates of 0LI with added hydrogens

TYROSINE-PROTEIN KINASE ABL INHIBITOR CHEMBL1862 TYROSINE-PROTEIN KINASE ABL P00519 TYROSINE-PROTEIN KINASE ABL1 HOMO SAPIENS ENZYME KINASE PROTEIN KINASE TK ABLANSM (in French)

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