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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
AMFENAC (is an active metabolite)

AMFENAC


ATC S01BC10

SENSORY
ANTIINFLAMMATORY
NONSTEROIDAL ANTI-INFLAMMATORY (NSAID) PRODRUG
TREATMENT OF PAIN AND INFLAMMATION ASSOCIATED WITH CATARACT SURGERY
CONVERTED BY OCULAR TISSUE HYDROLASES TO AMFENAC
INHIBITOR THE ACTION OF PROSTAGLANDIN H SYNTHASE (CYCLOOXYGENASE)

-

Cmax 1.65 NANOMOLAR

Tmax 0.75 HOUR

PPB 99.1 PERCENT

PROSTAGLANDIN H SYNTHASE (CYCLOOXYGENASE)

Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

2 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
NEPAFENAC (has an active metabolite)

NEPAFENAC


ATC S01BC10

SENSORY
ANTIINFLAMMATORY
NONSTEROIDAL ANTI-INFLAMMATORY (NSAID) PRODRUG
TREATMENT OF PAIN AND INFLAMMATION ASSOCIATED WITH CATARACT SURGERY
CONVERTED BY OCULAR TISSUE HYDROLASES TO AMFENAC
INHIBITOR THE ACTION OF PROSTAGLANDIN H SYNTHASE (CYCLOOXYGENASE)

OPHTHALMIC

Cmax 1.22 NANOMOLAR

Tmax 0.5 HOUR

PROSTAGLANDIN H SYNTHASE (CYCLOOXYGENASE)

Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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