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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DIGOXIN
| DIGOXIN | CARDIOVASCULAR | INJECTION ORAL | Tmax 2 HOUR F 70 PERCENT VD 266 LITER (65 KILOGRAM) PPB 25 PERCENT Cl 6.6 LITER / HOUR (65 KILOGRAM) HT 42 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | SODIUM-POTASSIUM ATPASE PDB 4RET (CRYSTAL STRUCTURE OF THE NA,K-ATPASE E2P-DIGOXIN COMPLEX WITH BOUND MAGNESIUM) LIGAND CODE = DGX (link to the list of PDB complexes) Download experimental 3D coordinates of DGX with added hydrogens | Sodium,potassium-transporting ATPase UNIPROT P05023 ATP1A1 more at DrugCentral | EMA | |||
