GABAPENTIN (is an active metabolite) | GABAPENTIN | ATC N02BF01
NERVOUS SYSTEM ANALGESIC MODERATE-TO-SEVERE PRIMARY RESTLESS LEGS SYNDROME (RLS) IN ADULTS ANTIEPILEPTIC POSTHERPETIC NEURALGIA (PHN) GABA RECEPTOR AGONIST | ORAL | Cmax 16.26 MICROMOLAR (600 MILLIGRAM OF GABAPENTIN ENACARBIL) F 75 PERCENT VD 76 LITER PPB 3 PERCENT Cl 7.6 LITER / HOUR HT 5.5 HOUR SOLUBILITY FREELY SOLUBLE IN WATER | VOLTAGE-GATED CALCIUM CHANNEL (PMID26680202) PDB 2COI (CRYSTAL STRUCTURE OF OXIDIZED HUMAN CYTOSOLIC BRANCHED-CHAIN AMINOTRANSFERASE COMPLEXED WITH GABAPENTIN) LIGAND CODE = GBN (link to the list of PDB complexes) Download experimental 3D coordinates of GBN with added hydrogens | Voltage-dependent calcium channel subunit alpha-2,delta-1 UNIPROT P54289 CACNA2D1 -- Voltage-dependent calcium channel subunit alpha-2,delta-2 UNIPROT Q9NY47 CACNA2D2 more at DrugCentral | EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank |
GABAPENTIN ENACARBIL (has an active metabolite) | GABAPENTIN ENACARBIL | ATC N02BF01
NERVOUS SYSTEM MODERATE-TO-SEVERE PRIMARY RESTLESS LEGS SYNDROME (RLS) IN ADULTS ANTIEPILEPTIC POSTHERPETIC NEURALGIA (PHN) GABAB AGONIST | ORAL | SOLUBILITY 0.5 MILLIGRAM / MILLILITER IN WATER | VOLTAGE-GATED CALCIUM CHANNEL (PMID26680202) | Voltage-dependent calcium channel subunit alpha-2,delta-1 UNIPROT P54289 CACNA2D1 -- Voltage-dependent calcium channel subunit alpha-2,delta-2 UNIPROT Q9NY47 CACNA2D2 more at DrugCentral | EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank |