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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
LURASIDONE

LURASIDONE


ATC N05AE05

NERVOUS SYSTEM
ANTIPSYCHOTIC
SCHIZOPHRENIA
OF BENZISOTHIAZOL DERIVATIVES
ANTAGONIST

ORAL

VD 6173 LITER (40 MILLIGRAM)

PPB 99 PERCENT

Cl 234 LITER / HOUR (40 MILLIGRAM)

HT 18 HOUR (40 MILLIGRAM)

SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER

DOPAMINE D2 ANTAGONIST (KI=0.994 NANOMOLAR)
5-HT2A ANTAGONIST (KI=0.47 NANOMOLAR)
5-HT7 ANTAGONIST (KI=0.495 NANOMOLAR)
ALPHA2C-ADRENERGIC RECEPTOR ANTAGONIST (KI=10.8 NANOMOLAR)
5-HT1A RECEPTOR PARTIAL AGONIST (KI=6.38 NANOMOLAR)
ALPHA2A ADRENERGIC RECEPTORS ANTAGONIST (KI=40.7 NM)

DOPAMINE D2 RECEPTOR ANTAGONIST CHEMBL217 DOPAMINE D2 RECEPTOR P14416 D(2) DOPAMINE RECEPTOR HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 SMALLMOL MONOAMINE RECEPTOR DOPAMINE RECEPTORANSM (in French)

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