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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
TOLVAPTAN

TOLVAPTAN


ATC C03XA01

CARDIOVASCULAR
DIURETIC
VASOPRESSIN V2-RECEPTOR ANTAGONIST
HYPERVOLEMIC AND EUVOLEMIC HYPONATREMIA

ORAL

VD 195 LITER (65 KILOGRAM)

PPB 99 PERCENT

Cl 15.6 LITER / HOUR (65 KILOGRAM)

HT 12 HOUR

ARGININE VASOPRESSIN RECEPTOR 2

VASOPRESSIN V2 RECEPTOR ANTAGONIST CHEMBL1790 VASOPRESSIN V2 RECEPTOR P30518 VASOPRESSIN V2 RECEPTOR HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 PEPTIDE SHORT PEPTIDE VASOPRESSIN AND OXYTOCIN RECEPTORANSM (in French)

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