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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
TENOFOVIR (is an active metabolite)

TENOFOVIR


ATC J05AR06
ATC J05AR08
ATC J05AR12
ATC J05AR27
ATC J05AR24
ATC J05AR11
ATC J05AF07
ATC J05AR03

ANTIINFECTIVE
ANTIVIRAL
ANTIRETROVIRAL
NUCLEOTIDE ANALOG HIV-1 REVERSE TRANSCRIPTASE INHIBITOR AND
HBV REVERSE TRANSCRIPTASE INHIBITOR
CHRONIC HEPATITIS B IN ADULTS

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Cmax 0.578 MICROMOLAR (300 MILLIGRAM)

F 25 PERCENT

VD 84.5 LITER (65 KILOGRAM)

PPB 7 PERCENT

Cl 3.4 LITER / HOUR (EQN)

HT 17 HOUR

HIV REVERSE TRANSCRIPTASE

PDB 8BVS (CRYO-EM STRUCTURE OF RAT SLC22A6 BOUND TO TENOFOVIR)

LIGAND CODE = TFO (link to the list of PDB complexes)

Download experimental 3D coordinates of TFO with added hydrogens

Reverse transcriptase,RNaseH UNIPROT Q72547 pol

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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