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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CAPSAICIN
| CAPSAICIN | MUSCULO-SKELETAL SYSTEM | TOPICAL | Cmax 15 NANOMOLAR HT 1.6 HOUR SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER | TRPV1 CATION CHANNEL PDB 2N27 (COMPETITIVE INHIBITION OF TRPV1 CALMODULIN INTERACTION BY VANILLOIDS) LIGAND CODE = 4DY (link to the list of PDB complexes) Download experimental 3D coordinates of 4DY with added hydrogens | Transient receptor potential cation channel subfamily V member 1 UNIPROT Q8NER1 TRPV1 more at DrugCentral | EMA | |||
