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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ABIRATERONE (is an active metabolite)
| ABIRATERONE |
ANTINEOPLASTIC | - | Cmax 0.64 MICROMOLAR (1000 MILLIGRAM) VD 19.6 LITER PPB 99 PERCENT Cl 1.1 LITER / HOUR (EQN) HT 12 HOUR | 17 ALPHA-HYDROXYLASE/C17,20-LYASE (CYP17) PDB 4NKV (HUMAN STEROIDOGENIC CYTOCHROME P450 17A1 MUTANT A105L WITH INHIBITOR ABIRATERONE) LIGAND CODE = AER (link to the list of PDB complexes) Download experimental 3D coordinates of AER with added hydrogens | Steroid 17-alpha-hydroxylase,17,20 lyase UNIPROT P05093 CYP17A1 more at DrugCentral | EMA | |||
