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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
DALFAMPRIDINE

DALFAMPRIDINE


ATC N07XX07

NERVOUS SYSTEM
MULTIPLE SCLEROSIS
BROAD SPECTRUM POTASSIUM ION CHANNELS INHIBITOR (KV)
INDICATED TO IMPROVE WALKING IN PATIENTS WITH MULTIPLE SCLEROSIS (MS)

ORAL

Cmax 0.318 MICROMOLAR (10 MILLIGRAM)

F 96 PERCENT

VD 169 LITER (65 KILOGRAM)

PPB 98 PERCENT

Cl 20 LITER / HOUR (EQN)

HT 5.8 HOUR

SOLUBILITY SOLUBLE IN WATER

SHAKER
KCNA

VOLTAGE-GATED POTASSIUM CHANNEL BLOCKER CHEMBL2362996 VOLTAGE-GATED POTASSIUM CHANNEL O43525 POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 3 HOMO SAPIENS ION CHANNEL VGC K VG KANSM (in French)

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