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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PAZOPANIB
| PAZOPANIB | ANTINEOPLASTIC | ORAL | Cmax 132.9 MICROMOLAR (800 MILLIGRAM) Tmax 3 HOUR PPB 99 PERCENT HT 30.9 HOUR (800 MILLIGRAM) SOLUBILITY PRACTICALLY INSOLUBLE ABOVE PH 4 IN WATER | VEGFR-1 VEGFR-2 VEGFR-3 PDGFR-ALPHA PDGRF-BETA FGFR-1 FGFR-3 KIT ITK LCK TRANSMEMBRANE GLYCOPROTEIN RECEPTOR TYROSINE KINASE (C-FMS) | Platelet-derived growth factor receptor beta UNIPROT P09619 PDGFRB -- Mast,stem cell growth factor receptor Kit UNIPROT P10721 KIT more at DrugCentral | EMA | |||
