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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was usedPrimary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
PAZOPANIB

PAZOPANIB


ATC L01EX03

ANTINEOPLASTIC
PROTEIN KINASE INHIBITORS
RENAL CELL CARCINOMA
SOFT TISSUE SARCOMA

ORAL

Cmax 132.9 MICROMOLAR (800 MILLIGRAM)

Tmax 3 HOUR

PPB 99 PERCENT

HT 30.9 HOUR (800 MILLIGRAM)

SOLUBILITY PRACTICALLY INSOLUBLE ABOVE PH 4 IN WATER

VEGFR-1
VEGFR-2
VEGFR-3
PDGFR-ALPHA
PDGRF-BETA
FGFR-1
FGFR-3
KIT
ITK
LCK
TRANSMEMBRANE GLYCOPROTEIN RECEPTOR TYROSINE KINASE (C-FMS)

Platelet-derived growth factor receptor beta UNIPROT P09619 PDGFRB -- Mast,stem cell growth factor receptor Kit UNIPROT P10721 KIT

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

VigiAccess
SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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