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INN

Class

Route (list)

PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)

Primary Target and PDB code of Protein-Drug complex

Targets from DrugCentral

Links

ASENAPINE

ATC N05AH05

ANTIPSYCHOTICS
5-HT2A RECEPTOR AGONIST
NERVOUS SYSTEM
SCHIZOPHRENIA
BIPOLAR DISORDER
HIGH AFFINITY FOR SEROTONIN 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5, 5-HT6, AND 5-HT7 RECEPTORS (KI VALUES OF 2.5, 4.0, 0.06, 0.16, 0.03, 1.6, 0.25, AND 0.13 NM), DOPAMINE D2, D3, D4, AND D1 RECEPTORS (KI VALUES OF 1.3, 0.42, 1.1, AND 1.4 NM), ALPHA1 AND ALPHA2-ADRENERGIC RECEPTORS (KI VALUES OF 1.2 AND 1.2 NM), AND HISTAMINE H1 RECEPTORS (KI VALUE 1.0 NM), AND MODERATE AFFINITY FOR H2 RECEPTORS (KI VALUE OF 6.2 NM)

SUBLINGUAL TRANSDERMAL

Cmax 14 NANOMOLAR (5 MILLIGRAM)

F 35 PERCENT (5 MILLIGRAM)

VD 1462 LITER (65 KILOGRAM)

PPB 95 PERCENT

Cl 52 LITER / HOUR

HT 24 HOUR

5-HT2A RECEPTOR (KI = 0.06 NANOMOLAR)
D2 RECEPTOR (KI = 1.3 NANOMOLAR)

D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A

more at DrugCentral

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