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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| RUFINAMIDE
| RUFINAMIDE | NERVOUS SYSTEM | ORAL | Tmax 5 HOUR F 85 PERCENT (600 MILLIGRAM) VD 50 LITER (3200 MILLIGRAM / DAY) PPB 34 PERCENT Cl 4.3 LITER / HOUR (EQN) HT 8 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | SODIUM CHANNELS (EC50 = 3.8 MICROMOLAR) | Sodium channel alpha subunit UNIPROT P35498 SCN1A more at DrugCentral | EMA | |||
