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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
RUFINAMIDE

RUFINAMIDE


ATC N03AF03

NERVOUS SYSTEM
ANTIEPILEPTIC
PROLONGATION OF THE INACTIVE STATE OF THE CHANNEL
INHIBITOR

ORAL

F 85 PERCENT (600 MILLIGRAM)

VD 50 LITER (3200 MILLIGRAM / DAY)

PPB 34 PERCENT

Cl 4.3 LITER / HOUR (EQN)

HT 8 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER

SODIUM CHANNELS (EC50 = 3.8 MICROMOLAR)

SODIUM CHANNEL ALPHA SUBUNIT BLOCKER CHEMBL2331043 SODIUM CHANNEL ALPHA SUBUNIT P35498 SODIUM CHANNEL PROTEIN TYPE 1 SUBUNIT ALPHA HOMO SAPIENS ION CHANNEL VGC VG NAANSM (in French)

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