ELTROMBOPAG | ELTROMBOPAG | ATC B02BX05
BLOOD THROMBOPOIETIN RECEPTOR AGONIST (TPO) THROMBOCYTOPENIA CHRONIC IMMUNE (IDIOPATHIC) THROMBOCYTOPENIA (ITP) INTERACTS WITH THE TRANSMEMBRANE DOMAIN OF THE HUMAN TPO-RECEPTOR AND INITIATES SIGNALING CASCADES THAT INDUCE PROLIFERATION AND DIFFERENTIATION OF MEGAKARYOCYTES FROM BONE MARROW PROGENITOR CELLS | ORAL | Cmax 28.7 MICROMOLAR (75 MILLIGRAM) Tmax 4 HOUR F 52 PERCENT PPB 99 PERCENT HT 26.5 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN AQUEOUS BUFFER ACROSS A PH RANGE OF 1 TO 7.4 AND IS SPARINGLY SOLUBLE IN WATER | THROMBOPOIETIN | Thrombopoietin receptor UNIPROT P40238 MPL more at DrugCentral | EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank |