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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
ELTROMBOPAG

ELTROMBOPAG


ATC B02BX05

BLOOD
THROMBOPOIETIN RECEPTOR AGONIST (TPO)
THROMBOCYTOPENIA
CHRONIC IMMUNE (IDIOPATHIC) THROMBOCYTOPENIA (ITP)
INTERACTS WITH THE TRANSMEMBRANE DOMAIN OF THE HUMAN TPO-RECEPTOR AND INITIATES SIGNALING CASCADES THAT INDUCE PROLIFERATION AND DIFFERENTIATION OF MEGAKARYOCYTES FROM BONE MARROW PROGENITOR CELLS

ORAL

Cmax 28.7 MICROMOLAR (75 MILLIGRAM)

Tmax 4 HOUR

F 52 PERCENT

PPB 99 PERCENT

HT 26.5 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN AQUEOUS BUFFER ACROSS A PH RANGE OF 1 TO 7.4 AND IS SPARINGLY SOLUBLE IN WATER

THROMBOPOIETIN

THROMBOPOIETIN RECEPTOR AGONIST CHEMBL1864 THROMBOPOIETIN RECEPTOR P40238 THROMBOPOIETIN RECEPTOR HOMO SAPIENS MEMBRANE RECEPTORANSM (in French)

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