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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PLERIXAFOR
| PLERIXAFOR | IMMUNOMODULATING | SUBCUTANEOUS | VD 19.5 LITER (65 KILOGRAM) PPB 58 PERCENT Cl 3.3 LITER / HOUR (EQN) HT 4 HOUR (0.24 MILLIGRAM / KILOGRAM) | ALPHA-CHEMOKINE RECEPTOR CXCR4 PDB 8U4P (STRUCTURE OF AMD3100-BOUND CXCR4, GI COMPLEX) LIGAND CODE = VH6 (link to the list of PDB complexes) Download experimental 3D coordinates of VH6 with added hydrogens | C-X-C chemokine receptor type 4 UNIPROT P61073 CXCR4 more at DrugCentral | EMA | |||
