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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CLINDAMYCIN (is an active metabolite)
| CLINDAMYCIN |
ANTIINFECTIVES | ORAL | Cmax 5.89 MICROMOLAR (150 MILLIGRAM) VD 51.3 LITER (65 KILOGRAM) PPB 94 PERCENT Cl 17.5 LITER / HOUR (65 KILOGRAM) HT 2.4 HOUR | 50S RIBOSOMAL SUBUNIT PDB 3JZ0 (LINB COMPLEXED WITH CLINDAMYCIN AND AMPCPP) LIGAND CODE = CLY (link to the list of PDB complexes) Download experimental 3D coordinates of CLY with added hydrogens | 50S RIBOSOMAL PROTEIN L10 P0A7J6 50S RIBOSOMAL PROTEIN L10 SHIGELLA FLEXNERI UNCLASSIFIED | ANSM (in French) | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CLINDAMYCIN PHOSPHATE (has an active metabolite)
| CLINDAMYCIN PHOSPHATE |
ANTIINFECTIVES | INJECTION TOPICAL VAGINAL INTRAVENOUS | SOLUBILITY SOLUBLE ESTER | 50S RIBOSOMAL SUBUNIT | BACTERIAL 70S RIBOSOME INHIBITOR CHEMBL2363135 BACTERIAL 70S RIBOSOME 23S RIBOSOMAL RNA BACTERIA | ANSM (in French) | |||
