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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| SAPROPTERIN (is an active metabolite)
| SAPROPTERIN SEPIAPTERIN | NATURAL MOLECULE (link) METABOLISM | ORAL | Cmax 1.79 MICROMOLAR Tmax 3.5 HOUR VD 11433 LITER PPB 32.7 PERCENT Cl 1498 LITER / HOUR HT 6.7 HOUR SOLUBILITY SOLUBLE IN WATER | PHENYLALANINE HYDROXYLASE PDB 8XZN (CRYSTAL STRUCTURE OF FOLE RIBOSWITCH WITH BH4) LIGAND CODE = H4B (link to the list of PDB complexes) Download experimental 3D coordinates of H4B with added hydrogens | Phenylalanine-4-hydroxylase UNIPROT P00439 PAH more at DrugCentral | EMA | |||
