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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
SAPROPTERIN

SAPROPTERINNATURAL MOLECULE (link)


ATC A16AX07

METABOLISM
AGONIST
TREATMENT OF HYPERPHENYLALANINAEMIA (HPA)
REDUCTION OF PHENYLALANINE CONCENTRATION IN PATIENTS WITH PHENYLKETONURIA (PKU)
COFACTOR FOR THE ENZYME PHENYLALANINE HYDROXYLASE (PAH). TREATMENT WITH BH4 CAN ACTIVATE RESIDUAL PAH AND IMPROVE THE NORMAL OXIDATIVE METABOLISM OF PHE, AND DECREASE PHE LEVELS
TREATMENT OF TETRAHYDROBIOPTERIN (BH4) DEFICIENCY

ORAL

Tmax 3.5 HOUR

HT 6.7 HOUR

SOLUBILITY SOLUBLE IN WATER

PHENYLALANINE HYDROXYLASE

PHENYLALANINE-4-HYDROXYLASE ACTIVATOR CHEMBL3076 PHENYLALANINE-4-HYDROXYLASE P00439 PHENYLALANINE-4-HYDROXYLASE HOMO SAPIENS ENZYME REDUCTASEANSM (in French)

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