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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
AMBRISENTAN

AMBRISENTAN


ATC C02KX02
ATC C02KX52

CARDIOVASCULAR
ANTIHYPERTENSIVE
ENDOTHELIN RECEPTOR ANTAGONIST
TREATMENT OF PULMONARY ARTERIAL HYPERTENSION (PAH)
AMBRISENTAN IS A SUBSTRATE OF P-GP

ORAL

VD 22 LITER (EQN)

PPB 99 PERCENT

Cl 1.71 LITER / HOUR

HT 9 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER

ENDOTHELIN TYPE-A RECEPTOR (ETA) (KI = 0.011 NANOMOLAR)

ENDOTHELIN RECEPTOR, ET-A/ET-B ANTAGONIST CHEMBL2096678 ENDOTHELIN RECEPTOR, ET-A/ET-B P24530 ENDOTHELIN B RECEPTOR HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 PEPTIDE SHORT PEPTIDE ENDOTHELIN RECEPTORANSM (in French)

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