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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was usedPrimary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
AMBRISENTAN

AMBRISENTAN


ATC C02KX02
ATC C02KX52

CARDIOVASCULAR
ANTIHYPERTENSIVE
ENDOTHELIN RECEPTOR ANTAGONIST
TREATMENT OF PULMONARY ARTERIAL HYPERTENSION (PAH)
AMBRISENTAN IS A SUBSTRATE OF P-GP

ORAL

Cmax 912 NANOMOLAR

Tmax 1.5 HOUR

PPB 99 PERCENT

Cl 1.71 LITER / HOUR

HT 9 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER

ENDOTHELIN TYPE-A RECEPTOR (ETA) (KI = 0.011 NANOMOLAR)

PDB 8XVK (CRYO-EM STRUCTURE OF ETAR BOUND WITH AMBRISENTAN)

LIGAND CODE = A1D5J (link to the list of PDB complexes)

Download experimental 3D coordinates of A1D5J with added hydrogens

Endothelin-1 receptor UNIPROT P25101 EDNRA

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

VigiAccess
SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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