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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| APREPITANT (is an active metabolite)
| APREPITANT | METABOLISM | ORAL INTRAVENOUS | Cmax 6.9 MICROMOLAR VD 70 LITER PPB 95 PERCENT Cl 4.4 LITER / HOUR (EQN) HT 11 HOUR | P/NEUROKININ-1 (NK1) RECEPTOR PDB 6HLO (CRYSTAL STRUCTURE OF THE NEUROKININ 1 RECEPTOR IN COMPLEX WITH THE SMALL MOLECULE ANTAGONIST APREPITANT) LIGAND CODE = GBQ (link to the list of PDB complexes) Download experimental 3D coordinates of GBQ with added hydrogens | Substance-P receptor UNIPROT P25103 TACR1 more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| FOSAPREPITANT (has an active metabolite)
| FOSAPREPITANT | METABOLISM | INTRAVENOUS | SOLUBILITY FREELY SOLUBLE IN WATER | P/NEUROKININ-1 (NK1) RECEPTOR | Substance-P receptor UNIPROT P25103 TACR1 more at DrugCentral | EMA | |||
