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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
DESVENLAFAXINE (is an active metabolite)

DESVENLAFAXINE


ATC N06AX23

NERVOUS SYSTEM
ANTIDEPRESSANTS
SELECTIVE SEROTONIN AND NOREPINEPHRINE REUPTAKE INHIBITOR (SNRI)
TREATMENT OF MAJOR DEPRESSIVE DISORDER [MDD]

ORAL

Cmax 1.1 MICROMOLAR

Tmax 3 HOUR

F 80 PERCENT

VD 370 LITER (65 KILOGRAM)

PPB 30 PERCENT

Cl 26 LITER / HOUR (65 KILOGRAM)

HT 11 HOUR

SOLUBILITY SOLUBLE IN WATER PH DEPENDENT

SEROTONIN AND NOREPINEPHRINE REUPTAKE

PDB 4MMC (CRYSTAL STRUCTURE OF LEUBAT (DELTA6 MUTANT) IN COMPLEX WITH DESVENLAFAXINE)

LIGAND CODE = 29J (link to the list of PDB complexes)

Download experimental 3D coordinates of 29J with added hydrogens

NOREPINEPHRINE TRANSPORTER INHIBITOR CHEMBL222 NOREPINEPHRINE TRANSPORTER P23975 SODIUM-DEPENDENT NORADRENALINE TRANSPORTER HOMO SAPIENS TRANSPORTER ELECTROCHEMICAL SLC SLC06ANSM (in French)

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