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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| METHYLNALTREXONE
| METHYLNALTREXONE |
NERVOUS SYSTEM | SUBCUTANEOUS ORAL | Cmax 1.10 MICROMOLAR (0.5 MILLIGRAM/KILLOGRAM) VD 71.5 LITER (65 KILOGRAM) PPB 13 PERCENT Cl 6.1 LITER / HOUR (EQN) HT 8 HOUR | DELTA-TYPE OPIOID RECEPTOR KAPPA-TYPE OPIOID RECEPTOR MU-TYPE OPIOID RECEPTOR | Mu-type opioid receptor UNIPROT P35372 OPRM1 -- Kappa-type opioid receptor UNIPROT P41145 OPRK1 more at DrugCentral | EMA | |||
