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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
ROTIGOTINE

ROTIGOTINE


ATC N04BC09

NERVOUS SYSTEM
NON-ERGOLINE DOPAMINE AGONISTS
TREATMENT OF SIGNS AND SYMPTOMS OF PARKINSON DISEASE AND RESTLESS LEGS SYNDROME

TRANSDERMAL

Cmax 3.8 NANOMOLAR

VD 5460 LITER (65 KILOGRAM)

PPB 92 PERCENT

Cl 630 LITER / HOUR (EQN)

HT 6 HOUR

DOPAMINE RECEPTOR

D2-LIKE DOPAMINE RECEPTOR AGONIST CHEMBL2331075 D2-LIKE DOPAMINE RECEPTOR P14416 D(2) DOPAMINE RECEPTOR HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 SMALLMOL MONOAMINE RECEPTOR DOPAMINE RECEPTORANSM (in French)

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