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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ZOLEDRONIC ACID
| ZOLEDRONIC ACID | MUSCULO-SKELETAL SYSTEM | INTRAVENOUS IV INJECTION | VD 39 LITER (65 KILOGRAM) PPB 40 PERCENT Cl 8.5 LITER / HOUR (65 KILOGRAM) HT 146 HOUR SOLUBILITY SPARINGLY SOLUBLE IN WATER | PDB 4KQ5 (CRYSTAL STRUCTURE OF HUMAN FARNESYL PYROPHOSPHATE SYNTHASE MUTANT (Y204A) COMPLEXED WITH MG AND ZOLEDRONATE) LIGAND CODE = ZOL (link to the list of PDB complexes) Download experimental 3D coordinates of ZOL with added hydrogens | Farnesyl pyrophosphate synthase UNIPROT P14324 FDPS more at DrugCentral | EMA | |||
