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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
MEQUINOL DISCONTINUED

MEQUINOLNATURAL MOLECULE (link)


ATC D11AX06

DERMATOLOGICAL
DEPIGMENTANT
SUBSTRATE FOR THE ENZYME TYROSINASE AND ACTS AS A COMPETITIVE INHIBITOR OF THE FORMATION OF MELANIN PRECURSORS

TOPICAL

Cmax 80 NANOMOLAR

TYROSINASE

PDB 5K1M (CRYSTAL STRUCTURE OF OXIDIZED SHEWANELLA YELLOW ENZYME 4 (SYE4) IN COMPLEX WITH P-METHOXYPHENOL)

LIGAND CODE = 4KS (link to the list of PDB complexes)

Download experimental 3D coordinates of 4KS with added hydrogens

Tyrosinase UNIPROT P14679 TYR

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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