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session 52020 - Total of 3 hits - Display hits per page:

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1	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
GLYCEROL PHENYLBUTYRATE (has an active metabolite)	GLYCEROL PHENYLBUTYRATE	ATC A16AX09 NITROGEN-BINDING AGENT FOR CHRONIC UREAC CYCLE DISORDERS (UCDS) AMMONIA SCAVENGER SUBSTRATE METABOLIZED BY LIPASES (PANCREATIC TRIGLYCERIDE LIPASE, CARBOXYL ESTER LIPASE, AND PANCREATIC LIPASERELATED PROTEIN 2) AND BY ESTERASES IN HUMAN PLASMA (IN VITRO)	ORAL	SOLUBILITY INSOLUBLE IN WATER	PANCREATIC TRIGLYCERIDE LIPASE CARBOXYL ESTER LIPASE PANCREATIC LIPASE RELATED PROTEIN 2 HUMAN ESTERASES	Unknown more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank
2	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
PHENYLACETATE (is an active metabolite)	PHENYLACETATE	NATURAL MOLECULE (link) ATC A16AX09 NITROGEN-BINDING AGENT FOR CHRONIC UREAC CYCLE DISORDERS (UCDS) AMMONIA SCAVENGER SUBSTRATE METABOLIZED BY PHENYLACETYL-COA: L-GLUTAMINE-N-ACETYLTRANSFERASE COMPOUND THAT CONJUGATES WITH GLUTAMINE VIA ACETYLATION TO FORM PHENYLACETYLGLUTAMINE PHENYLACETYLGLUTAMINE THEN IS EXCRETED BY THE KIDNEYS ON A MOLAR BASIS, IT IS COMPARABLE TO UREA (EACH CONTAINING TWO MOLES OF NITROGEN) THEREFORE, PHENYLACETYLGLUTAMINE PROVIDES AN ALTERNATE VEHICLE FOR WASTE NITROGEN EXCRETION	-	Cmax 205.8 MICROMOLAR Tmax 3.7 HOUR PPB 51 PERCENT HT 1.15 HOUR SOLUBILITY SOLUBLE IN WATER	PHENYLACETYL-COA: L-GLUTAMINE-N-ACETYLTRANSFERASE PDB 2ISF (CRYSTAL STRUCTURE OF C298A W219Y ALDOSE REDUCTASE COMPLEXED WITH PHENYLACETIC ACID) LIGAND CODE = PAC (link to the list of PDB complexes) Download experimental 3D coordinates of PAC with added hydrogens	Unknown more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank
3	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
PHENYLBUTYRATE (is an active metabolite) (has an active metabolite)	PHENYLBUTYRATE	ATC A16AX03 ATC N07XX19 METABOLISM SUPPLEMENT DECREASED ELEVATED PLASMA AMMONIA GLUTAMINE LEVELS ANTIHYPERAMMONEMIC UREA CYCLE DISORDERS RAPIDLY METABOLIZED TO PHENYLACETATE NITROGEN-BINDING AGENT FOR CHRONIC UREAC CYCLE DISORDERS (UCDS)	ORAL	Cmax 1.32 MILLIMOLAR (5 GRAMS) Tmax 1 HOUR PPB 89 PERCENT HT 0.77 HOUR SOLUBILITY SOLUBLE IN WATER	PHENYLACETYL-COA: L-GLUTAMINE-N-ACETYLTRANSFERASE PDB 3TZ2 (CRYSTAL STRUCTURE OF BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE KINASE, PHENYLBUTYRATE COMPLEX) LIGAND CODE = CLT (link to the list of PDB complexes) Download experimental 3D coordinates of CLT with added hydrogens	Unknown more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank