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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| NALMEFENE
| NALMEFENE | NERVOUS SYSTEM | INTRAMUSCULAR INTRAVENOUS SUBCUTANEOUS NASAL | F 99 PERCENT VD 559 LITER (65 KILOGRAM) PPB 45 PERCENT Cl 52 LITER / HOUR (65 KILOGRAM) HT 10.8 HOUR SOLUBILITY FREELY SOLUBLE IN WATER UP TO 130 MILLIGRAM / MILLILITER | OPIOID RECEPTOR | Mu-type opioid receptor UNIPROT P35372 OPRM1 -- Kappa-type opioid receptor UNIPROT P41145 OPRK1 more at DrugCentral | EMA | |||
