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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
TRIMETREXATE DISCONTINUED

TRIMETREXATE


ATC P01AX07

ANTIPARASITIC
ANTINEOPLASTIC
ANTIPROTOZOALS
ANTIBIOTICS
ANTIFUNGAL AGENTS
FOLIC ACID ANTAGONISTS
INHIBITOR
TREATMENT OF MODERATE-TO-SEVERE PNEUMOCYSTIS CARINII PNEUMONIA (PCP) IN IMMUNOCOMPROMISED PATIENTS, INCLUDING PATIENTS WITH THE ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS)

INJECTION

VD 34.6 LITER

PPB 95 PERCENT

Cl 3.9 LITER / HOUR

HT 11 HOUR

SOLUBILITY TRIMETREXATE GLUCURONATE IS SOLUBLE IN WATER (> 50 MILLIGRAM / MILLILITER) WHEREAS TRIMETREXATE FREE BASE IS PRACTICALLY INSOLUBLE IN WATER (< 0.1 MILLIGRAM / MILLILITER)

DIHYDROFOLATE REDUCTASE (DHFR)

PDB 1BZF (NMR SOLUTION STRUCTURE AND DYNAMICS OF THE COMPLEX OF LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE WITH THE NEW LIPOPHILIC ANTIFOLATE DRUG TRIMETREXATE)

LIGAND CODE = TMQ (link to the list of PDB complexes)

Download experimental 3D coordinates of TMQ with added hydrogens

DIHYDROFOLATE REDUCTASE INHIBITOR CHEMBL1926 DIHYDROFOLATE REDUCTASE P16184 DIHYDROFOLATE REDUCTASE PNEUMOCYSTIS CARINII ENZYME REDUCTASEANSM (in French)

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