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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
TORSEMIDE

TORSEMIDE


ATC C03CA04

CARDIOVASCULAR
ANTIHYPERTENSIVE AGENTS
DIURETICS
ANTIINFLAMMATORY
INHIBITOR OF THE NA+/K+/2CL- CARRIER SYSTEM IN NEPHRON
TREATMENT OF EDEMA ASSOCIATED WITH CONGESTIVE HEART FAILURE, RENAL DISEASE, OR HEPATIC DISEASE

ORAL INJECTION

F 80 PERCENT

VD 13.5 LITER

PPB 99 PERCENT

Cl 2.6 LITER / HOUR (EQN)

HT 3.5 HOUR

NA+/K+/2CL- CARRIER SYSTEM

SODIUM-(POTASSIUM)-CHLORIDE COTRANSPORTER 2 INHIBITOR CHEMBL1874 SODIUM-(POTASSIUM)-CHLORIDE COTRANSPORTER 2 Q13621 SOLUTE CARRIER FAMILY 12 MEMBER 1 HOMO SAPIENS TRANSPORTER ELECTROCHEMICAL SLC SLC12ANSM (in French)

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