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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
FLUTICASONE FUROATE

FLUTICASONE FUROATE


ATC R01AD12
ATC R03BA09
ATC R03AK10
ATC R03AL08

RESPIRATORY
ANTIINFLAMMATORY
CORTICOSTEROIDS AGONIST
TREATMENT OF SYMPTOMS OF SEASONAL AND PERENNIAL ALLERGIC RHINITIS

NASAL INHALATION

Cmax NOT QUANTIFIABLE (ROUTE = INTRANASAL)

F 1.26 PERCENT

VD 608 LITER

PPB 99 PERCENT

Cl 58.7 LITER / HOUR

HT 15.1 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER

HUMAN GLUCOCORTICOID RECEPTOR

PDB 3CLD (LIGAND BINDING DOMAIN OF THE GLUCOCORTICOID RECEPTOR COMPLEXED WITH FLUTICAZONE FUROATE)

LIGAND CODE = GW6 (link to the list of PDB complexes)

Download experimental 3D coordinates of GW6 with added hydrogens

GLUCOCORTICOID RECEPTOR AGONIST CHEMBL2034 GLUCOCORTICOID RECEPTOR P04150 GLUCOCORTICOID RECEPTOR HOMO SAPIENS TRANSCRIPTION FACTOR NUCLEAR RECEPTOR NR3 NR3C NR3C1ANSM (in French)

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